Akynzeo® (netupitant/palonosetron) as a basis of modern prophylaxis of chemotherapy-induced nausea and vomiting

Currently, nausea and vomiting during chemotherapy are a common adverse event affecting quality duration of life patients. Introduction several classes antiemetics correct use various medications in the form combination scheme prophylaxis allow to effectively control these events. However, incidence remains high clinical practice, according surveys doctors underestimate frequency complications This is primarily caused by patient noncompliance using for delayed prevention due complicated schemes dosing antiemetic administration. Combination peroral drug netupitant + palonosetron (Akynzeo®) seems optimal solution this event. One-time administration Akynzeo® prior course allows omit 5-HT3 receptor agonists NK1 agonist which increases compliance taking simplified therapy regimen, decreases vomiting, patients’ life.